Voltage Sensor Movements
نویسندگان
چکیده
منابع مشابه
Voltage Sensor Movements
The voltage dependence of K , Na , and Ca 2 channels is brought about by a voltage sensor that moves 12–13 e 0 across the entire electric field (Schoppa et al., 1992; Hirschberg et al., 1996; Noceti et al., 1996). In the case of Shaker K channel it is known which residues are responsible for this large amount of gating charge. This was found by measuring the total gating charge movement per cha...
متن کاملMolecular mechanism of voltage sensor movements in a potassium channel.
Voltage-gated potassium channels are six-transmembrane (S1-S6) proteins that form a central pore domain (4 x S5-S6) surrounded by four voltage sensor domains (S1-S4), which detect changes in membrane voltage and control pore opening. Upon depolarization, the S4 segments move outward carrying charged residues across the membrane field, thereby leading to the opening of the pore. The mechanism of...
متن کاملFast and Slow Voltage Sensor Movements in HERG Potassium Channels
HERG encodes an inwardly-rectifying potassium channel that plays an important role in repolarization of the cardiac action potential. Inward rectification of HERG channels results from rapid and voltage-dependent inactivation gating, combined with very slow activation gating. We asked whether the voltage sensor is implicated in the unusual properties of HERG gating: does the voltage sensor move...
متن کاملEngineering of a Genetically Encodable Fluorescent Voltage Sensor Exploiting Fast Ci-VSP Voltage-Sensing Movements
Ci-VSP contains a voltage-sensing domain (VSD) homologous to that of voltage-gated potassium channels. Using charge displacement ('gating' current) measurements we show that voltage-sensing movements of this VSD can occur within 1 ms in mammalian membranes. Our analysis lead to development of a genetically encodable fluorescent protein voltage sensor (VSFP) in which the fast, voltage-dependent ...
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The Tokamak Physics Experiment (TPX) was a steady-state, tokamak to be built at the Princeton Plasma Physics Laboratory. It would have been the first tokamak in the world with an entirely superconducting magnet system. The project was terminated by the United States Congress in 1995. However, most of the TPX mission has been adopted recently by the South Korean project KSTAR (Korean Superconduc...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2002
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.20028660